Like, what, two years ago? :b :lol
Anyway, back to the villain... how about a woman? Annie Wilkes from "Misery". Love her because she has a great sense of (crazy and dark) humor.
Another woman: Nicole Wallace (Olivia d'Abo), from "Law & Order: Criminal Intent". She's Detective Robert Goren's (Vincent D'onofrio) nemesis. Wow! No words.
Hey, Kai Winn is a woman ! Not obvious from the name though, I admit.
And the borg queen kinda is. The female shapeshifter, .. she is while in solid form, sorta...
Annie Wilkes is freaky, no doubt. brrrr...